Institute for Macromolecular Chemistry, University of Freiburg, Freiburg, Germany.
Langmuir. 2013 Mar 26;29(12):4092-5. doi: 10.1021/la304075c. Epub 2013 Mar 11.
When polymeric nanoparticles (NPs) are formed by nanoprecipitation, which is a nucleation-growth process, the control over size requires changing the polymer concentration or solvent composition. Here, we demonstrate that the NP size can be controlled independent of polymer variables by introducing a polyelectrolyte (PE) in the aqueous phase. PEs that exhibit hydrogen bonding (H-bonding) yield a reduction in NP size, whereas PEs that do not possess this characteristic promote the formation of larger NPs. The observed effect can be attributed to the formation of a diffusional barrier around the NP in the form of a dense shell. This principle of controlling NP size is not limited to polymers and can also be employed in the production of lipid NPs.
当通过纳米沉淀形成聚合物纳米粒子 (NPs) 时，这是一个成核-生长过程，控制尺寸需要改变聚合物浓度或溶剂组成。在这里，我们通过在水相中引入聚电解质 (PE) 来证明可以独立于聚合物变量来控制 NP 尺寸。表现出氢键 (H-bonding) 的 PEs 会导致 NP 尺寸减小，而不具有这种特性的 PEs 则会促进更大 NPs 的形成。观察到的效果可以归因于在 NP 周围形成致密壳形式的扩散屏障。这种控制 NP 尺寸的原理不仅限于聚合物，也可用于脂质 NPs 的生产。
