Department of Obstetrics & Gynecology, Seoul National University College of Medicine, Seoul, Korea.
Reprod Sci. 2013 Sep;20(9):1083-9. doi: 10.1177/1933719113477480. Epub 2013 Feb 25.
Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as a reliable marker of acute renal injury and is produced at the maternal-fetal interface but its role in preeclampsia has not been systematically examined. This study investigated whether plasma NGAL concentrations changed in patients with preeclampsia at diagnosis compared to normotensive controls.
A case-control study was performed. Plasma was collected from women with preeclampsia and normotensive controls matched for age, gestational age, and body mass index. Plasma NGAL concentrations were measured by specific enzyme-linked immunosorbent assay.
Patients with preeclampsia had significantly higher NGAL concentrations than controls (median [range]: 203.8 ng/mL [66.1-575.4] vs. 122.8 ng/mL [7.0-669.7]; P = .047). In subgroup analysis, patients with severe preeclampsia had significantly higher NGAL concentrations than those with mild preeclampsia. Plasma NGAL concentrations were positively correlated with the amount of proteinuria in women with preeclampsia (P = .003).
Plasma NGAL concentrations were significantly elevated in women with preeclampsia versus normotensive controls, and concentrations appear to be associated with the severity of the disease.
中性粒细胞明胶酶相关脂质运载蛋白（NGAL）已成为急性肾损伤的可靠标志物，在母体-胎儿界面产生，但它在子痫前期中的作用尚未得到系统研究。本研究旨在探讨子痫前期患者与正常血压对照组相比，其血浆 NGAL 浓度在诊断时是否发生变化。
采用病例对照研究。收集子痫前期患者和年龄、孕龄和体重指数匹配的正常血压对照组的血浆。通过特异性酶联免疫吸附试验测量血浆 NGAL 浓度。
子痫前期患者的 NGAL 浓度明显高于对照组（中位数[范围]：203.8ng/mL[66.1-575.4] vs. 122.8ng/mL[7.0-669.7]；P=0.047）。亚组分析显示，重度子痫前期患者的 NGAL 浓度明显高于轻度子痫前期患者。子痫前期患者的血浆 NGAL 浓度与蛋白尿的量呈正相关（P=0.003）。
与正常血压对照组相比，子痫前期患者的血浆 NGAL 浓度显著升高，且浓度似乎与疾病的严重程度相关。
