Dohmen P M
Department of Cardiac Surgery, Heart Centre Leipzig, University of Leipzig, Leipzig, Germany.
HSR Proc Intensive Care Cardiovasc Anesth. 2012;4(2):89-93.
Several prostheses are available to replace degenerative diseased aortic valves with unique advantages and disadvantages. Bioprotheses show excellent hemodynamic behavior and low risk of thromboembolic complications, but are limited by tissue deterioration. Mechanical heart valves have extended durability, but permanent anticoagulation is mandatory. Tissue engineering created a new generation heart valve, which overcome limitations of biological and mechanical heart valves due to remodelling, regeneration and growth potential. Several publications are available in using tissue engineered heart valves in right ventricular outflow tract reconstruction. Limited experiences are available on these heart valves implanted into the systemic circulation. This overview shows the current state on the development of tissue engineered aortic heart valves.
有几种假体可用于替换退行性病变的主动脉瓣，各有独特的优缺点。生物假体具有出色的血流动力学表现和较低的血栓栓塞并发症风险，但受组织退化限制。机械心脏瓣膜耐久性更强，但必须进行永久性抗凝。组织工程制造出了新一代心脏瓣膜，由于具备重塑、再生和生长潜力，克服了生物和机械心脏瓣膜的局限性。关于在右心室流出道重建中使用组织工程心脏瓣膜已有多篇文献发表。将这些心脏瓣膜植入体循环的经验有限。本综述展示了组织工程主动脉心脏瓣膜的当前发展状况。
