Eghafona N O, Emejuaiwe S O
Department of Microbiology, Ahmadu Bello University, Zaria, Nigeria.
Antiviral Res. 1990 Feb;13(2):75-9. doi: 10.1016/0166-3542(90)90023-z.
Lymphocytes characterized by in vitro rosette formation with sheep erythrocytes were enumerated in blood of normal and measles virus-vaccinated monkeys. Rosetting lymphocyte counts increased significantly as a result of vaccination. Concomitantly, HAI-antibody, undetectable before vaccination, became detectable, suggesting that the simple and inexpensive technique of enumerating rosetting lymphocytes can be used as an alternative to other more cumbersome and expensive methods for evaluation of development of cell-mediated immunity following measles virus vaccination.
在正常和接种麻疹病毒疫苗的猴子血液中，对以体外与绵羊红细胞形成玫瑰花结为特征的淋巴细胞进行了计数。接种疫苗后，玫瑰花结形成淋巴细胞计数显著增加。同时，接种前无法检测到的血凝抑制（HAI）抗体变得可检测到，这表明，对于评估麻疹病毒疫苗接种后细胞介导免疫的发展情况，计数玫瑰花结形成淋巴细胞这种简单且廉价的技术可作为其他更繁琐、昂贵方法的替代方法。
