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体外冲击波碎石术治疗小儿肾结石: 一种估计结石清除率的多变量分析模型。

Extracorporeal shockwave lithotripsy for renal stones in pediatric patients: a multivariate analysis model for estimating the stone-free probability.

机构信息

Urology Department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.

出版信息

Int J Urol. 2013 Dec;20(12):1205-10. doi: 10.1111/iju.12132. Epub 2013 Feb 26.

Abstract

OBJECTIVES

To define factors affecting the stone-free rate of extracorporeal shockwave lithotripsy in the treatment of pediatric renal calculi, and to establish a regression model for pretreatment prediction of stone-free probability.

METHODS

From January 1999 through February 2012, 207 children with mean age 6.4 ± 3.8 years underwent shockwave lithotripsy with Dornier Lithotripter S for treatment of renal stones. The stone-free rate was evaluated 3 months after the last shockwave lithotripsy session with non-contrast computed tomography. Treatment success was defined as complete clearance of the stones with no residual fragments. Multivariate logistic regression analysis was used to identify independent risk factors and to predict the probability of being stone free.

RESULTS

The mean length of the stone was 11.6 ± 4 mm. The stone-free rate was 71%. Independent factors that adversely affect stone-free rate were increasing stone length and calyceal site of the stone. Relative risks for not being free of stones were 1.123 for stone length, 2.673 for stones in the upper or middle calyx and 4.208 for lower calyx stones.

CONCLUSION

Stone length and location are prognostic factors determining stone-free rate after shockwave lithotripsy for renal calculi in pediatric patients. Based on our analysis, shockwave lithotripsy should be recommended for renal pelvis stones up to 24 mm, upper or middle calyceal stones up to 15 mm and lower calyceal stones up to 11 mm.

摘要

目的

明确影响体外冲击波碎石术治疗儿童肾结石结石清除率的因素,并建立预测结石清除率的预测模型。

方法

1999 年 1 月至 2012 年 2 月,207 例平均年龄为 6.4±3.8 岁的儿童接受了 Dornier Lithotripter S 体外冲击波碎石术治疗肾结石。最后一次体外冲击波碎石治疗 3 个月后,采用非增强 CT 评估结石清除率。治疗成功定义为结石完全清除,无残留碎片。多因素 logistic 回归分析用于识别独立的危险因素,并预测结石清除的概率。

结果

结石平均长度为 11.6±4mm。结石清除率为 71%。独立影响结石清除率的因素为结石长度增加和结石位于肾盂。结石长度、肾盂或中上盏结石、下盏结石的无结石相对风险分别为 1.123、2.673、4.208。

结论

结石长度和位置是影响儿童肾结石体外冲击波碎石术后结石清除率的预后因素。根据我们的分析,对于肾盂结石,冲击波碎石术应推荐用于 24mm 以下的结石;对于肾盂或中上盏结石,应推荐用于 15mm 以下的结石;对于下盏结石,应推荐用于 11mm 以下的结石。

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