Kurihara M, Izumi T, Denda T, Mahara K, Isomura S, Hanada E
Dept. of Gastroenterology, Toyosu Hospital, Showa University, Tokyo.
Gan To Kagaku Ryoho. 1990 Apr;17(4 Pt 2):887-94.
Changes with time in quality of life (QOL) in patients who had undergone chemotherapy for various types of inoperable gastrointestinal diseases were investigated. The items studied included appetite, general feeling, sleep, fatigue, pain, familial understanding and cooperation, association with friends and colleagues, anxiety concerning the disease, expectations concerning treatment and daily life activities. These 10 items were recorded by the patients for 2-4 weeks in five grades by a combination of the analog scale and category scale methods, with the exception of association with friends and colleagues, which showed few entries, the following relations with antitumor effects were seen at the following average QOL values in the total scores for the nine items: In PR cases (n = 7), 15.6 before treatment, 19.7 during treatment and 14.8 after treatment; in NC cases (n = 11), 19.4 before treatment, 20 during treatment and 19.1 after treatment; and in PD cases (n = 4), 17.0 before treatment, 22.8 during treatment, and 22.8 after treatment. The above 10 items were surveyed simultaneously with a face scale (Arthritis and Rheumatism, Vol. 29, No,7, 906-909, 1986). Five faces considered appropriate for a five-stage evaluation were used, and the Spearman coefficient of correlation was calculated with a combination of all of the above 10 items. The face scale showed correlation in the sequence of general feeling sleep greater than activities of daily life greater than anxiety concerning the disease greater than fatigue. As a result of a nonmetric type component analysis, the data could be reduced to four dimensions with appetite, fatigue, activities of daily life, general feeling and face as the first principal component; expectations concerning treatment, understanding and cooperation of family and association with friends as the second principal component; anxiety concerning the disease and sleep as the third principal component; and pain as the fourth principal component (cumulative contribution rate: 82.38). The first principal component was investigated using a logistic regression model. As a result, the face scale could be explained by the general feeling and the daily life activities. The weight was general feeling 3 and daily life activities 1. Therefore, it appears possible to utilize sufficiently the face scale in QOL surveys of cancer patients.
对因各种无法手术的胃肠道疾病接受化疗的患者的生活质量（QOL）随时间的变化进行了调查。研究的项目包括食欲、总体感觉、睡眠、疲劳、疼痛、家庭理解与合作、与朋友和同事的交往、对疾病的焦虑、对治疗的期望以及日常生活活动。除与朋友和同事的交往这一项目记录较少外，其余这10个项目由患者采用模拟量表和分类量表相结合的方法，分五个等级记录2至4周。在9个项目的总分中，不同疗效情况的患者平均QOL值与抗肿瘤效果呈现以下关系：部分缓解（PR）病例（n = 7），治疗前15.6，治疗期间19.7，治疗后14.8；病情稳定（NC）病例（n = 11），治疗前19.4，治疗期间20，治疗后19.1；疾病进展（PD）病例（n = 4），治疗前17.0，治疗期间22.8，治疗后22.8。上述10个项目同时采用面部量表进行调查（《关节炎与风湿病》，第29卷，第7期，906 - 909页，1986年）。使用了五张被认为适合五阶段评估的面部表情图片，并计算了上述所有10个项目组合的Spearman相关系数。面部量表显示相关性顺序为：总体感觉、睡眠大于日常生活活动大于对疾病的焦虑大于疲劳。经过非度量型成分分析，数据可缩减为四个维度，以食欲、疲劳、日常生活活动、总体感觉和面部表情为第一主成分；对治疗的期望、家庭的理解与合作以及与朋友的交往为第二主成分；对疾病的焦虑和睡眠为第三主成分；疼痛为第四主成分（累积贡献率：82.38）。使用逻辑回归模型对第一主成分进行了研究。结果表明，面部量表可以用总体感觉和日常生活活动来解释。权重为总体感觉3，日常生活活动1。因此，在癌症患者的QOL调查中似乎可以充分利用面部量表。
