Ishihara Y, Sakai H, Nukariya N, Kobayashi K, Yoneda S, Matsuoka R, Hojou N, Nishiwaki Y, Hoshi A, Kuratomi Y
Dept. of Hygiene & Public Health, Tokyo Women's Medical College.
Gan To Kagaku Ryoho. 1995 Jul;22(8):1087-93.
The effects of cisplatin and carboplatin in QOL were studied using a QOL questionnaire seeking to conform their validity and reliability in lung cancer patients. The questionnaire was composed of eleven items; appetite, feeling, sleep, mental fatigue, pain, anxiety, daily activity, abdominal and respiratory conditions, linear analog and face scale as global scale. The data were collected from 21 patients treated with cisplatin (Cis group) and 9 patients administered carboplatin (Carbo group). Chronological changes of QOL were measured by AUC (area under the curve) method. 1) The total score of 9 items, linear analog and face scales rose immediately to the highest levels (worse) after treatment and maintained this level for 1 week in the Cis group. The Carbo group levels rose from 3 days and returned to the control level at 9 days after treatment. 2) AUC of the total score, linear analog and face scales in the Cis group increased significantly when compared with those of the Carbo group. 3) When compared with the Cis and Carbo groups the physiological and active scales were not different, but the psychological scale showed a significant difference between the two groups. 4) The total score of the psychological scale correlated the abdominal score in the Cis group, but not in the Carbo group. 5) Sleep and mental fatigue were related to the aggravation of QOL at 5-6 days after Carboplatin treatment. These results suggested that this QOL questionnaire had sufficient sensitivity to reflect any chemotherapeutic side-effects. 6) AUC is useful method in chronological evaluation of QOL.
使用一份生活质量问卷研究顺铂和卡铂对生活质量的影响，该问卷旨在验证其在肺癌患者中的有效性和可靠性。问卷由11个项目组成：食欲、感觉、睡眠、精神疲劳、疼痛、焦虑、日常活动、腹部和呼吸状况、线性模拟评分法和面部表情量表作为整体评分。数据收集自21例接受顺铂治疗的患者（顺铂组）和9例接受卡铂治疗的患者（卡铂组）。采用曲线下面积（AUC）法测量生活质量的时间变化。1） 顺铂组治疗后9个项目、线性模拟评分法和面部表情量表的总分立即升至最高水平（最差），并维持该水平1周。卡铂组治疗后3天水平上升，9天后恢复至对照水平。2） 顺铂组总分、线性模拟评分法和面部表情量表的AUC与卡铂组相比显著增加。3） 与顺铂组和卡铂组相比，生理和活动量表无差异，但心理量表在两组之间存在显著差异。4） 顺铂组心理量表总分与腹部评分相关，而卡铂组则不相关。5） 睡眠和精神疲劳与卡铂治疗后5 - 6天生活质量的恶化有关。这些结果表明，这份生活质量问卷对反映任何化疗副作用具有足够的敏感性。6） AUC是生活质量时间评估的有用方法。
