What determines the kinetics of the slow afterhyperpolarization (sAHP) in neurons?
作者信息
Larsson H Peter
机构信息
Department of Physiology and Biophysics, University of Miami, Miami, Florida, USA.
出版信息
Biophys J. 2013 Jan 22;104(2):281-3. doi: 10.1016/j.bpj.2012.11.3832.
Abstract
摘要
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What determines the kinetics of the slow afterhyperpolarization (sAHP) in neurons?是什么决定了神经元中慢后超极化（sAHP）的动力学？
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Essential role for phosphatidylinositol 4,5-bisphosphate in the expression, regulation, and gating of the slow afterhyperpolarization current in the cerebral cortex.磷脂酰肌醇 4,5-二磷酸在大脑皮层慢后超极化电流的表达、调节和门控中的必需作用。
J Neurosci. 2011 Dec 14;31(50):18303-12. doi: 10.1523/JNEUROSCI.3203-11.2011.
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Single K ATP channel opening in response to action potential firing in mouse dentate granule neurons.单个 KATP 通道在响应小鼠齿状颗粒神经元动作电位发射时打开。
J Neurosci. 2011 Jun 8;31(23):8689-96. doi: 10.1523/JNEUROSCI.5951-10.2011.
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Visinin-like neuronal calcium sensor proteins regulate the slow calcium-activated afterhyperpolarizing current in the rat cerebral cortex.类视蛋白神经元钙传感器蛋白调节大鼠大脑皮层中的缓慢钙激活后超极化电流。
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The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels.特定的慢后超极化抑制剂 UCL2077 是癫痫相关 KCNQ 通道的亚型选择性阻断剂。
Mol Pharmacol. 2010 Dec;78(6):1088-95. doi: 10.1124/mol.110.066100. Epub 2010 Sep 15.
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The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus.KCNQ5钾通道介导小鼠海马体超极化后电流的一个组成部分。
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Ageing Res Rev. 2004 Nov;3(4):383-406. doi: 10.1016/j.arr.2004.07.001.
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SKCa channels mediate the medium but not the slow calcium-activated afterhyperpolarization in cortical neurons.小电导钙激活钾通道介导皮层神经元中等时程而非慢时程的钙激活后超极化。
J Neurosci. 2004 Apr 7;24(14):3537-42. doi: 10.1523/JNEUROSCI.0380-04.2004.
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