姑息治疗研究：我们团队在过去 25 年中获得的经验教训。
Palliative care research: lessons learned by our team over the last 25 years.
机构信息
Department of Palliative Care and Rehabilitation Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
出版信息
Palliat Med. 2013 Dec;27(10):939-51. doi: 10.1177/0269216313477177. Epub 2013 Feb 26.
BACKGROUND
In the last 25 years, palliative care has made major progress as an interdisciplinary specialty that addresses quality-of-life issues for patients with life-limiting illnesses and their families. Research by numerous investigators has contributed to our increasing body of knowledge to support an evidence-based practice.
AIM
We highlight some lessons learned by our group in the process of conducting palliative care research, focusing in particular on symptom assessment; the management of pain, fatigue, cachexia, dyspnea, delirium, and opioid-induced neurotoxicity; and outcomes of our palliative care program.
DESIGN
Narrative review of selected literature, focusing on studies conducted by our group.
DATA SOURCES
This article is based on the Second Vittorio Ventafridda Memorial Lecture by Dr Eduardo Bruera, delivered at the European Association for Palliative Care, Trondheim, Norway on 8 June 2012.
RESULTS
For each topic, we review some of the pivotal studies in palliative care, discuss the challenges in research design, and outline possible directions for future research.
CONCLUSIONS
We conclude by sharing some of what we learned about the processes, pearls, and pitfalls of palliative care research.
背景
在过去的 25 年中，姑息治疗作为一门跨学科专业取得了重大进展，为患有生命有限疾病的患者及其家属解决了生活质量问题。许多研究人员的研究为我们日益增长的知识体系做出了贡献，以支持循证实践。
目的
我们重点介绍了我们小组在进行姑息治疗研究过程中所学到的一些经验教训，特别关注症状评估；疼痛、疲劳、恶病质、呼吸困难、谵妄和阿片类药物引起的神经毒性的管理；以及我们姑息治疗计划的结果。
设计
对选定文献进行叙述性综述，重点关注我们小组进行的研究。
资料来源
本文基于 Eduardo Bruera 博士在 2012 年 6 月 8 日于挪威特隆赫姆举行的欧洲姑息治疗协会第二届 Vittorio Ventafridda 纪念演讲。
结果
对于每个主题，我们回顾了姑息治疗中的一些关键研究，讨论了研究设计中的挑战，并概述了未来研究的可能方向。
结论
我们最后分享了一些我们在姑息治疗研究的过程、要点和陷阱中学到的东西。
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