Hu Zhenhua, Gao Song, Gao Jian, Hou Rui, Liu Chuan, Liu Juanjuan, Li Beibei, Liu Dawo, Zhang Shulan, Lin Bei
Department of Obstetrics and Gynecology, Shengjing Hospital affiliated to China Medical University, Shenyang 110004, Liaoning Province, China.
Int J Mol Sci. 2012 Nov 23;13(12):15588-600. doi: 10.3390/ijms131215588.
To measure Lewis y and integrin α(5)β(1) expression in epithelial ovarian carcinoma and to correlate the levels of these molecules with ovarian carcinoma chemotherapy and prognosis.
The study population included 34 ovarian carcinoma patients with chemotherapeutic drug-resistance, six partially drug-sensitive cases, and 52 drug-sensitive cases (92 total). Immunochemistry was used to determine expression of Lewis y antigen and integrin α(5)β(1) in ovarian carcinoma tissues, and correlation of these molecules with chemotherapy resistance was further investigated, Multi-factor logistic regression analysis was applied to investigate: age, surgical stage, grade, subtype of patient cases, metastasis of lymph nodes, residual tumor size, expression levels of Lewis y antigen and integrin α(5)β(1) correlation with ovarian carcinoma chemotherapy resistance.
The expression rates of Lewis y antigen and integrins α(5) and β(1) were significantly greater in the drug-resistant group (91.17%, 85.29%, 88.24%) than the partially sensitive (50.00%, 33.33%, 50.00%) or sensitive groups (61.54%, 57.69%, 55.77%). Binary logistic regression analysis revealed that surgical stage, residual tumor size, and expression of integrin α(5) and Lewis y in ovarian carcinoma tissues were independent risk factors for chemotherapeutic drug resistance.
Overexpression of Lewis y and integrin α(5) are strong risk factors for chemotherapeutic drug resistance in ovarian carcinoma patients.
检测上皮性卵巢癌中Lewis y和整合素α(5)β(1)的表达，并将这些分子的水平与卵巢癌化疗及预后相关联。
研究人群包括34例对化疗耐药的卵巢癌患者、6例部分药物敏感病例和52例药物敏感病例（共92例）。采用免疫化学方法测定卵巢癌组织中Lewis y抗原和整合素α(5)β(1)的表达，并进一步研究这些分子与化疗耐药的相关性。应用多因素logistic回归分析研究：患者年龄、手术分期、分级、病例亚型、淋巴结转移、残余肿瘤大小、Lewis y抗原和整合素α(5)β(1)的表达水平与卵巢癌化疗耐药的相关性。
耐药组中Lewis y抗原及整合素α(5)和β(1)的表达率（分别为91.17%、85.29%、88.24%）显著高于部分敏感组（分别为50.00%、33.33%、50.00%）和敏感组（分别为61.54%、57.69%、55.77%）。二元logistic回归分析显示，手术分期、残余肿瘤大小以及卵巢癌组织中整合素α(5)和Lewis y的表达是化疗耐药的独立危险因素。
Lewis y和整合素α(5)的过表达是卵巢癌患者化疗耐药的强危险因素。
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