Department of Obstetrics, Gynecology and Reproductive Sciences, University of California at San Francisco and San Francisco General Hospital, San Francisco, CA 94110, USA.
J Perinatol. 2013 Mar;33(3):235-8. doi: 10.1038/jp.2012.70.
Severe insulin resistance as a complication of diabetes in pregnancy is seen with increasing frequency. Treatment with large doses of insulin (>300 units perday) can be practically difficult. A woman with preexisting Type 2 diabetes mellitus and poor glycemic control presented in early pregnancy requiring over 1000 units of insulin daily. She was transitioned to subcutaneous U-500 (concentrated regular insulin) in combination with a rapid-acting insulin analog achieving good glycemic control and good maternal and fetal outcomes. U-500R insulin in conjunction with a rapid-acting insulin analog can be used safely in early pregnancy to improve glycemic control in severe insulin resistance due to pregestational diabetes.
妊娠糖尿病患者常出现严重胰岛素抵抗，且胰岛素用量日益增加（>300U/天）。治疗难度较大。一名患有 2 型糖尿病且血糖控制不佳的孕妇在孕早期需要每天注射超过 1000 单位的胰岛素。她改用 U-500（高浓度短效胰岛素）皮下注射，联合速效胰岛素类似物，以实现良好的血糖控制及母婴结局。U-500R 胰岛素联合速效胰岛素类似物可安全用于孕早期，改善因孕前糖尿病引起的严重胰岛素抵抗患者的血糖控制。
