Zhou Li, Fan Ling
Department of Obstetrics, Beijing Obstetrics & Gynecology Hospital, Capital Medical University, Beijing 100026, China.
Zhonghua Yi Xue Za Zhi. 2012 May 22;92(19):1334-6.
To explore the efficacy and safety of human aspart versus regular human insulin in women with gestational diabetes mellitus (GDM).
A total of 80 women with GDM during pregnancy delivered at our hospital divided into 2 groups: Group 1 with human aspart and regular human insulin N while Group 2 with regular human insulin R and N. The levels of glucose were compared before and after 2 h at breakfast, lunch and supper at Day 1, 3 and 5. And the outcomes of women and their babies were evaluated.
No significant difference in general characteristics existed between two groups. Except for breakfast of Day 3, no significant difference was found in terms of the amount of insulin, the time of satisfactory glucose level and delivery time point, etc. There was no significant inter-group difference in the outcomes of pregnant women and their babies.
The efficacy and safety of human aspart or regular human insulin are comparable for the women with gestational diabetes mellitus.
探讨门冬胰岛素与人胰岛素常规制剂治疗妊娠期糖尿病（GDM）孕妇的疗效及安全性。
选取我院收治的80例妊娠合并GDM孕妇，分为两组：1组使用门冬胰岛素与人胰岛素常规制剂N，2组使用人胰岛素常规制剂R与N。比较第1、3、5天早餐、午餐及晚餐后2小时血糖水平，并评估母婴结局。
两组孕妇一般特征无显著差异。除第3天早餐外，两组胰岛素用量、血糖达标时间及分娩时间等方面无显著差异。两组孕妇及其婴儿的结局无显著组间差异。
门冬胰岛素与人胰岛素常规制剂治疗妊娠期糖尿病孕妇的疗效及安全性相当。
