Robinson Institute, School of Paediatrics and Reproductive Health, Department of Obstetrics and Gynaecology, Univeristy of Adelaide, South Australia, Australia.
Int J Cancer. 2013 Nov 15;133(10):2263-76. doi: 10.1002/ijc.28127. Epub 2013 Mar 16.
As it was first characterized in 1997, the ADAMTS (A Disintegrin and Metalloprotease with ThromboSpondin motifs) metalloprotease family has been associated with many physiological and pathological conditions. Of the 19 proteases belonging to this family, considerable attention has been devoted to the role of its first member ADAMTS1 in cancer. Elevated ADAMTS1 promotes pro-tumorigenic changes such as increased tumor cell proliferation, inhibited apoptosis and altered vascularization. Importantly, it facilitates significant peritumoral remodeling of the extracellular matrix environment to promote tumor progression and metastasis. However, discrepancy exists, as several studies also depict ADAMTS1 as a tumor suppressor. This article reviews the current understanding of ADAMTS1 regulation and the consequence of its dysregulation in primary cancer and ADAMTS1-mediated pathways of cancer progression and metastasis.
自 1997 年首次被描述以来，ADAMTS（解整合素和金属蛋白酶与凝血酶敏感蛋白基序）金属蛋白酶家族与许多生理和病理状况有关。在属于该家族的 19 种蛋白酶中，人们对其第一个成员 ADAMTS1 在癌症中的作用给予了相当多的关注。ADAMTS1 的升高促进了促肿瘤变化，如肿瘤细胞增殖增加、凋亡抑制和血管生成改变。重要的是，它促进了肿瘤周围细胞外基质环境的显著重塑，以促进肿瘤的进展和转移。然而，也存在差异，因为一些研究也将 ADAMTS1 描绘为肿瘤抑制因子。本文综述了 ADAMTS1 调节的最新认识及其在原发性癌症中的失调后果，以及 ADAMTS1 介导的癌症进展和转移途径。
