Li C, Chalfie M
Department of Biological Sciences, Columbia University, New York, New York 10027.
Neuron. 1990 May;4(5):681-95. doi: 10.1016/0896-6273(90)90195-l.
One of the final stages in the development of egg-laying behavior in the nematode C. elegans is the organization of 8 motor neurons (2 HSN and 6 VC cells) and 8 muscles into a motor system to control the opening of the vulva. Using mutations that disrupt the development of specific components of the egg-laying system and laser microsurgery to ablate selected precursor cells, we have determined that the guidance of the egg-laying neurons and muscles, and in particular the VC neurons and vulval muscles, into the vulval region is dependent on interactions with surrounding epithelial and gonadal tissue and appears to be independent of neuron-neuron and neuron-muscle interactions. The development of the egg-laying system can be described as a series of cell interactions in which certain cells arise through induction and subsequently provide inductive cues themselves.
秀丽隐杆线虫产卵行为发育的最后阶段之一，是将8个运动神经元（2个HSN和6个VC细胞）和8块肌肉组织成一个运动系统，以控制阴门的打开。利用破坏产卵系统特定组件发育的突变以及激光显微手术切除选定的前体细胞，我们已经确定，产卵神经元和肌肉，特别是VC神经元和阴门肌肉，向阴门区域的引导依赖于与周围上皮和性腺组织的相互作用，并且似乎独立于神经元-神经元和神经元-肌肉的相互作用。产卵系统的发育可以描述为一系列细胞相互作用，其中某些细胞通过诱导产生，随后自身提供诱导信号。
