碘苯催化 N-取代脒与间氯过氧苯甲酸的 C-H 胺化反应。
Iodobenzene catalyzed C-H amination of N-substituted amidines using m-chloroperbenzoic acid.
机构信息
Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati-781039, India.
出版信息
Org Lett. 2013 Mar 15;15(6):1334-7. doi: 10.1021/ol400274f. Epub 2013 Feb 27.
PMID:23444897
Abstract
The oxidative C-H amination of N"-aryl-N'-tosyl/N'-methylsulfonylamidines and N,N'-bis(aryl)amidines has been accomplished using iodobenzene as a catalyst to furnish 1,2-disubstituted benzimidazoles in the presence of mCPBA as a terminal oxidant at room temperature. The reaction is general, and the target products can be obtained in moderate to high yields.
摘要
N"-芳基-N'-对甲苯磺酰基/N'-甲基磺酰基脒和 N,N'-双（芳基）脒的氧化 C-H 氨化反应已使用碘苯作为催化剂，在 mCPBA 作为末端氧化剂的存在下，在室温下完成，生成 1,2-二取代苯并咪唑。该反应具有普遍性，目标产物可以中等至高产率获得。
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