Nirmala C K, Nor Azlin M I, Harry S R, Lim P S, Shafiee M N, Nur Azurah A G, Omar M H, Hatta M D
Department of Obstetrics and Gynaecology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
J Obstet Gynaecol. 2013 Feb;33(2):191-3. doi: 10.3109/01443615.2012.741150.
Gestational trophoblastic disease (GTD) is a common problem among Asian ethnics. A total of 102 women with molar pregnancies between 1 January 2005 and 31 December 2010, were analysed. The aim of the study was to determine the outcome of all molar pregnancies in our institution. The local incidence of molar pregnancy was 2.6 per 1,000 deliveries. A total of 48 women (47.1%) had complete hydatidiform mole and another 54 (52.9%) had partial mole. The mean age of the women with molar pregnancies was 32.0 ± 7.9 years. The mean gestational age at initial diagnosis was 11 weeks ± 3 days. The majority (97 women, 95.1%) had symptoms of vaginal bleeding and 18 (17.6%) women had a uterus larger than dates. A total of 48 (47.1%) women had ultrasound scan findings of 'snow-storm' appearance. None of the women with uncomplicated molar pregnancy had evidence of relapse following one undetectable serum β-hCG level. Four out of the 102 women (3.9%) developed persistent trophoblastic disease before attaining one undetectable serum β-hCG level. All four women required single agent methotrexate and they remained in remission. The prognosis for uncomplicated molar pregnancy is good. Establishment of a National Trophoblastic Centre is recommended to maintain optimal outcome.
妊娠滋养细胞疾病（GTD）在亚洲人种中是一个常见问题。对2005年1月1日至2010年12月31日期间的102例葡萄胎妊娠女性进行了分析。本研究的目的是确定我们机构中所有葡萄胎妊娠的结局。葡萄胎妊娠的当地发病率为每1000例分娩中有2.6例。共有48名女性（47.1%）为完全性葡萄胎，另外54名（52.9%）为部分性葡萄胎。葡萄胎妊娠女性的平均年龄为32.0±7.9岁。初次诊断时的平均孕周为11周±3天。大多数（97名女性，95.1%）有阴道出血症状，18名（17.6%）女性子宫大于孕周。共有48名（47.1%）女性超声检查结果显示为“暴风雪”样外观。所有单纯性葡萄胎妊娠女性在血清β-hCG水平检测不到后均无复发迹象。102名女性中有4名（3.9%）在血清β-hCG水平检测不到之前发生了持续性滋养细胞疾病。所有4名女性均需要单药甲氨蝶呤治疗，且仍处于缓解状态。单纯性葡萄胎妊娠的预后良好。建议建立国家滋养细胞疾病中心以维持最佳结局。
