Mori Satoshi
Bone and Joint Surgery, Seirei Hamamatsu General Hospital, Japan.
Clin Calcium. 2013 Mar;23(3):365-70.
Atypical fractures of femoral shaft and pelvis occurred on the long-term bisphosphonate treatment patients have been first reported in 2005. Since then many cases have been reported, while the number of atypical fractures is small compared with that of bisphosphonate treatment patients. It is speculated that accumulation of microdamage induced by severely suppressed bone turnover causes clinical fatigue fracture.
2005年首次报道了长期接受双膦酸盐治疗的患者发生股骨干和骨盆非典型骨折的情况。自那时以来，已有许多病例被报道，然而与接受双膦酸盐治疗的患者数量相比，非典型骨折的数量较少。据推测，严重抑制骨转换所导致的微损伤积累会引起临床疲劳骨折。
