Hospital Neuropsiquiátrico Braulio A. Moyano, Buenos Aires, Argentina.
Rev Psiquiatr Salud Ment. 2011 Apr;4(2):96-100. doi: 10.1016/j.rpsm.2011.02.002. Epub 2011 May 19.
Capgras syndrome has originally been described as psychiatric syndrome. However, in the last few years reports of patients with this syndrome has significantly increased in patients with neurological, metabolic, and infectious diseases and those who consume alcohol. Different hypotheses have been proposed to explain the neurobiology of this very unusual symptom, such as changes in the dopamine circuit and specific dysfunctions in facial processing.
In this work we present a new case of Capgras syndrome, associated with an acute cocaine overdose, which was transient and reversible.
The neurobiological bases of this syndrome are analysed, along with their relationship with the changes induced by cocaine use. Thus, Capgras syndrome could be the expression of functional changes at frontal-temporal level, and the paralimbic region secondary to the consumption of psychoactive substances such as cocaine.
卡普格拉综合征最初被描述为一种精神科综合征。然而，在过去的几年中，患有这种综合征的患者在患有神经、代谢和传染病以及酗酒的患者中显著增加。已经提出了不同的假说来解释这种非常不寻常症状的神经生物学，例如多巴胺回路的变化和面部处理的特定功能障碍。
在这项工作中，我们报告了一例新的卡普格拉综合征病例，与急性可卡因过量有关，且该病例是短暂和可逆的。
分析了这种综合征的神经生物学基础及其与可卡因使用引起的变化的关系。因此，卡普格拉综合征可能是额颞叶水平功能变化的表现，以及边缘系统区域的变化，这是可卡因等精神活性物质使用的结果。
