From the *Hospital Universitari Vall d'Hebron, Pediatric Infectious Diseases and Immunodeficiencies Unit, Universitat Autònoma de Barcelona; †Department of Pediatrics, Hospital Sant Joan de Déu, Infectious Diseases Unit, Universitat de Barcelona, Barcelona; ‡Department of Pediatrics, Hospital Universitario La Paz, Infectious Diseases Unit; §Department of Pediatrics, Hospital Universitario Carlos III, Infectious Diseases Unit, Madrid; ¶Department of Pediatrics, Hospital San Joan d'Alacant, Infectious Diseases Unit, Alacant; ‖Department of Pediatrics, Hospital Virgen del Rocío, Infectious Diseases Unit, Sevilla; **Department of Pediatrics, Hospital General Universitario Gregorio Marañón, Infectious Diseases Unit; ††Laboratorio de Inmunobiología Molecular, Hospital General Universitario Gregorio Marañón, Madrid; ‡‡Department of Pediatrics, Hospital General de Castelló, Infectious Diseases Unit, Castelló; §§Department of Pediatrics, Hospital Josep Trueta, Infectious Diseases Unit, Girona; ¶¶Department of Pediatrics, Hospital Germans Trias i Pujol, Infectious Diseases Unit, Badalona, Barcelona; ‖‖Department of Pediatrics, Hospital Infantil Universitario Miguel Servet, Infectious Diseases Unit, Zaragoza; ***Department of Pediatrics, Hospital Asil de Granollers, Infectious Diseases Unit, Granollers; †††Department of Pediatrics, Hospital de Mataró, Infectius Diseases Unit, Mataró, Barcelona; and ‡‡‡Department of Pediatrics, Hospital Carlos Haya, Infectious Diseases Unit, Málaga, Spain.
Pediatr Infect Dis J. 2013 Sep;32(9):e377-9. doi: 10.1097/INF.0b013e31828e9b99.
Regular screening methods may miss the diagnosis of occult hepatitis B infection and seronegative hepatitis C virus infection in immunocompromised patients. A cross-sectional study within a Spanish cohort of HIV-infected children yielded 6 of 254 (2.4%) possible occult hepatitis B infection cases and 2 of 254 (0.8%) seronegative hepatitis C virus-infected patients. Implementation of occult hepatitis screening in the routine care of these children may be warranted.
常规筛查方法可能会漏诊免疫功能低下患者的隐匿性乙型肝炎感染和血清阴性丙型肝炎病毒感染。在西班牙一组感染 HIV 的儿童队列中进行的一项横断面研究发现 254 例患儿中有 6 例（2.4%）可能存在隐匿性乙型肝炎感染，254 例患儿中有 2 例（0.8%）血清阴性丙型肝炎病毒感染。这些患儿的常规护理中可能需要实施隐匿性肝炎筛查。
