Department of Zoology, JN Vyas University, Jodhpur, Rajasthan, India.
Biochem Genet. 2013 Jun;51(5-6):458-73. doi: 10.1007/s10528-013-9577-x. Epub 2013 Feb 28.
Transforming acidic coiled-coil proteins (TACC1, 2, and 3) are essential proteins associated with the assembly of spindle microtubules and maintenance of bipolarity. Dysregulation of TACCs is associated with tumorigenesis, but studies of microsatellite instability in TACC genes have not been extensive. Microsatellite or simple sequence repeat instability is known to cause many types of cancer. The present in silico analysis of SSRs in human TACC gene sequences shows the presence of mono- to hexa-nucleotide repeats, with the highest densities found for mono- and di-nucleotide repeats. Density of repeats is higher in introns than in exons. Some of the repeats are present in regulatory regions and retained introns. Human TACC genes show conservation of many repeat classes. Microsatellites in TACC genes could be valuable markers for monitoring numerical chromosomal aberrations and or cancer.
转化酸性卷曲螺旋蛋白（TACC1、2 和 3）是与纺锤体微管组装和双极性维持相关的必需蛋白。TACCs 的失调与肿瘤发生有关，但对 TACC 基因中的微卫星不稳定性的研究并不广泛。微卫星或简单重复序列不稳定性已知可导致多种类型的癌症。对人类 TACC 基因序列中 SSR 的计算机分析表明存在单核苷酸到六核苷酸重复，其中单核苷酸和二核苷酸重复的密度最高。重复的密度在内含子中高于外显子。一些重复存在于调节区域和保留的内含子中。人类 TACC 基因显示许多重复类别的保守性。TACC 基因中的微卫星可能是监测染色体数目异常和/或癌症的有价值的标记物。
