Department of Radiation Oncology, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA.
Support Care Cancer. 2013 Jul;21(7):2059-66. doi: 10.1007/s00520-013-1766-y. Epub 2013 Feb 28.
This study was conducted in order to characterize the prevalence of falls and functional impairments (FIs) and their association with chemotherapy-induced peripheral neuropathy (CIPN) in cancer survivors.
We analyzed baseline assessments from a phase III RCT in cancer survivors with self-reported CIPN scores of >4 out of 10. Patients completed the EORTC QLQ-CIPN-20 for neuropathy and reported falls in the previous 3 months. FIs were defined using the Activities of Daily Living subsection of the Vulnerable Elder's Scale. Associations of baseline characteristics and CIPN with falls and FIs were examined using logistic regression.
Of 421 patients, 11.9 % experienced recent falls and 26.6 % reported FIs. Motor neuropathy was the only factor associated with falls (OR = 1.127, p = 0.01). Factors associated with FIs included non-white race (OR = 0.335 white relative to non-white, 0.781, p = 0.01) and greater motor neuropathy scores (OR = 1.262, p < 0.0001).
CIPN, primarily motor, is associated with falls and FIs. Future prospective research should investigate the ability of motor neuropathy severity to predict falls.
本研究旨在描述癌症幸存者中跌倒和功能障碍（FIs）的发生率及其与化疗引起的周围神经病变（CIPN）的关系。
我们分析了一项针对癌症幸存者的 III 期 RCT 的基线评估，这些患者的自我报告 CIPN 评分超过 10 分中的 4 分。患者完成了 EORTC QLQ-CIPN-20 以评估周围神经病变，并报告了过去 3 个月内的跌倒情况。使用脆弱老年人量表的日常生活活动小节来定义 FIs。使用逻辑回归检查基线特征和 CIPN 与跌倒和 FIs 的关联。
在 421 名患者中，11.9%的患者最近经历过跌倒，26.6%的患者报告有 FIs。运动性神经病是唯一与跌倒相关的因素（OR=1.127，p=0.01）。与 FIs 相关的因素包括非白色人种（OR=0.335，白色人种相对非白色人种，0.781，p=0.01）和更严重的运动性神经病评分（OR=1.262，p<0.0001）。
CIPN，主要是运动性，与跌倒和 FIs 有关。未来的前瞻性研究应调查运动性神经病严重程度预测跌倒的能力。
