Colgate Australian Clinical Dental Research Centre, School of Dentistry, University of Adelaide, Frome Road, Adelaide, SA 5000, Australia.
Inflammopharmacology. 2013 Aug;21(4):321-38. doi: 10.1007/s10787-012-0165-1. Epub 2013 Feb 28.
Macrolide antibiotics have been found to possess not only antimicrobial properties, but also modulate inflammation. In this review the multi-faceted properties of azithromycin are discussed. Due to the unique anti-inflammatory and antimicrobial properties, macrolides, and especially azithromycin, are currently used for a number of conditions which have both an inflammatory and microbial component. For the same reason, azithromycin may be of value as an adjunct in the management of periodontitis which, although driven by an infectious component, is largely a result of uncontrolled chronic inflammation.
大环内酯类抗生素不仅具有抗菌特性，还可调节炎症。本文讨论了阿奇霉素的多方面特性。由于具有独特的抗炎和抗菌特性，大环内酯类药物，尤其是阿奇霉素，目前被用于多种既有炎症又有微生物成分的疾病。出于同样的原因，阿奇霉素可能对牙周炎的治疗有辅助作用，虽然牙周炎的驱动因素是感染，但主要还是由于不受控制的慢性炎症。
