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采用化学气相沉积法和爆轰法合成的碳粉的生物学特性。

Biological properties of carbon powders synthesized using chemical vapour deposition and detonation methods.

作者信息

Batory M, Batory D, Grabarczyk J, Kaczorowski W, Kupcewicz B, Mitura K, Nasti T H, Yusuf N, Niedzielski P

机构信息

Institute of Materials Science and Engineering, Technical University of Lodz, 1/15 Stefanowskiego Street, 90-924 Lodz, Poland.

出版信息

J Nanosci Nanotechnol. 2012 Dec;12(12):9037-46. doi: 10.1166/jnn.2012.6745.

Abstract

Carbon powders can be synthesized using variety of CVD and detonation methods. Several interesting properties of carbon powder particles make them a very attractive material examined in many laboratories all over the world. However there is a lack of information discussing investigation of carbon powders directed to its application in pharmaceutical-cosmetic industry and medicine. Earlier investigation results proved that diamond powders present properties fighting free radicals. Presented work discusses the influence of carbon powder particles manufactured using MW/RF PACVD, RF PACVD and detonation methods onto hydro-lipid skin coat. Before the biological examinations physicochemical properties of carbon powders were determined. Grain size, shape and chemical composition of carbon powders were determined using the scanning electron microscopy. Surface functional groups were characterized by IR Fourier-transform spectroscopy and X-ray photoelectron spectroscopy. Structure and phase composition were investigated by means of the Raman spectroscopy. Results of allergy tests performed on laboratory mice proved that carbon powder particles synthesized using different methods do not cause allergy. In the following stage, the group of 20 patients applied the formula including carbon powder on their face skin. The influence of carbon powder onto hydro-lipid skin coat was determined by measurement of such parameters as: pH reaction, skin temperature, lipid fotometry and level of hydration. Additionally, macro pictures of places where the cream had been applied were registered. As the result of the investigation it was found that powders synthesized using various methods present different physicochemical properties which may individually affect the face skin parameters. The noticeable improvement of hydro-lipid skin coat kilter was observed.

摘要

碳粉可以通过多种化学气相沉积(CVD)和爆轰方法合成。碳粉颗粒的几个有趣特性使其成为全球许多实验室研究的极具吸引力的材料。然而,缺乏关于碳粉在制药 - 化妆品行业和医学应用方面研究的信息。早期的研究结果证明,金刚石粉具有对抗自由基的特性。本文讨论了采用微波/射频等离子体辅助化学气相沉积(MW/RF PACVD)、射频等离子体辅助化学气相沉积(RF PACVD)和爆轰方法制造的碳粉颗粒对皮肤水脂膜的影响。在进行生物学检查之前,先测定了碳粉的物理化学性质。使用扫描电子显微镜测定了碳粉的粒度、形状和化学成分。通过红外傅里叶变换光谱和X射线光电子能谱对表面官能团进行了表征。利用拉曼光谱研究了结构和相组成。对实验小鼠进行的过敏测试结果证明,用不同方法合成的碳粉颗粒不会引起过敏。在接下来的阶段,20名患者在面部皮肤上涂抹了含有碳粉的配方产品。通过测量诸如pH反应、皮肤温度、脂质光度法和水合水平等参数来确定碳粉对皮肤水脂膜的影响。此外,还记录了涂抹面霜部位的宏观图片。研究结果发现,用各种方法合成的粉末呈现出不同的物理化学性质,这些性质可能会分别影响面部皮肤参数。观察到皮肤水脂膜平衡有明显改善。

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