Van Diem L, Grilliat J P
Department D of Internal Medicine and Allergy, University Hospital of Brabois, Vandoeuvre-les-Nancy, France.
Eur J Clin Pharmacol. 1990;38(4):389-90. doi: 10.1007/BF00315581.
A 46 year old woman had adverse reactions to paracetamol. Oral challenge tests with the drug showed that the reactions were dose-dependent and they reproduced similar symptoms consisting of vomiting, diarrhoea, pruritus, skin rashes, facial oedema, dyspnoea and hypotension. There was a marked increase in blood histamine but the complement components C3 and C4 remained at normal levels. Treatment with epinephrine and moderate doses of betamethasone brought fast recovery without any further complication.
一名46岁女性对扑热息痛有不良反应。对该药物进行的口服激发试验表明，这些反应呈剂量依赖性，且会重现类似症状，包括呕吐、腹泻、瘙痒、皮疹、面部水肿、呼吸困难和低血压。血液组胺显著升高，但补体成分C3和C4仍保持在正常水平。使用肾上腺素和中等剂量倍他米松治疗后迅速康复，未出现任何进一步并发症。
