碘化亚铜介导苄基氰化物合成 3-氰基吲哚衍生物。

Synthesis of 3-cyanoindole derivatives mediated by copper(I) iodide using benzyl cyanide.

机构信息

State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.

出版信息

J Org Chem. 2013 Apr 5;78(7):3374-8. doi: 10.1021/jo3028278. Epub 2013 Mar 11.

DOI:10.1021/jo3028278

PMID:23448701

Abstract

Copper-mediated direct and regioselective C3-cyanation of indoles using benzyl cyanide as the cyanide anion source is presented. A wide range of indoles undergo cyanation smoothly by employing a reaction system of copper(I) iodide under open-to-air vessels.

摘要

本文报道了一种铜介导的吲哚的直接、区域选择性 C3-氰化反应，使用苄基氰化物作为氰阴离子源。在开放空气容器中，采用碘化亚铜反应体系，可使多种吲哚顺利发生氰化反应。