铜介导的3-氰基咪唑并[1,2-a]吡啶的三组分合成
Copper-mediated three-component synthesis of 3-cyanoimidazo[1,2-a]pyridines.
作者信息
Wen Qiaodong, Lu Ping, Wang Yanguang
机构信息
Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China.
出版信息
Chem Commun (Camb). 2015 Oct 28;51(84):15378-81. doi: 10.1039/c5cc05821j.
PMID:26344490
Abstract
A copper-mediated three-component approach towards the synthesis of 3-cyanoimidazo[1,2-a]pyridines from 2-aminopyridines, acetophenones and benzyl cyanide was developed. This cascade reaction proceeds through a copper-mediated oxidative release of cyanide from benzyl cyanide, a copper-mediated Ortoleva-King reaction, and a copper-catalyzed cyanation.
摘要
开发了一种铜介导的三组分方法，用于从2-氨基吡啶、苯乙酮和苄基氰合成3-氰基咪唑并[1,2-a]吡啶。该串联反应通过铜介导的苄基氰中氰化物的氧化释放、铜介导的奥尔托莱瓦-金反应以及铜催化的氰化反应进行。
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