Department of Chemistry, Shanghai University, Shanghai 200444, China.
Org Lett. 2012 Sep 7;14(17):4614-7. doi: 10.1021/ol302070t. Epub 2012 Aug 20.
A palladium-catalyzed regioselective C-H cyanation of heteroarenes was achieved using tert-butyl isocyanide as "CN" source, which provides a new and unique strategy for the preparation of (hetero)aryl nitriles. Indoles, pyrroles, and aromatic rings could be efficiently cyanated through C-H bond activation with high regioselectivity.
钯催化的杂芳烃 C-H 氰化反应是通过叔丁基异氰酸酯作为 "CN" 源来实现的，这为（杂）芳基腈的制备提供了一种新的独特策略。吲哚、吡咯和芳环可以通过 C-H 键的活化高效地氰化，具有高区域选择性。
