Kusunoki-Nakamoto Fumiko, Matsukawa Takashi, Tanaka Masaki, Miyagawa Toji, Yamamoto Tomotaka, Shimizu Jun, Ikemura Masako, Shibahara Junji, Tsuji Shoji
Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan.
Intern Med. 2013;52(5):623-8. doi: 10.2169/internalmedicine.52.8785. Epub 2013 Mar 1.
Inflammatory myofibroblastic tumor (IMT) is a disease characterized by tumorous lesions consisting of myofibroblastic spindle cells and inflammatory cells that occur primarily in the soft tissues and viscera of children and young adults. Total excision is the most effective therapy. Steroids have been used to treat unresectable lesions with some success. We herein report a case of IMT involving the frontal bone accompanied by pachymeningitis. The tumor was characterized by an aggressive clinical course that was refractory to prednisolone. Performing total excision seemed difficult. Celecoxib and methotrexate were effective treatments. Our experience suggests the efficacy of celecoxib and methotrexate as alternatives for treating unresectable IMT.
炎性肌纤维母细胞瘤（IMT）是一种以肿瘤性病变为特征的疾病，该病变由肌纤维母细胞性梭形细胞和炎症细胞组成，主要发生于儿童和青年的软组织及内脏。完整切除是最有效的治疗方法。类固醇已被用于治疗无法切除的病变，取得了一定成功。我们在此报告一例累及额骨并伴有硬脑膜炎的IMT病例。该肿瘤的临床病程具有侵袭性，对泼尼松龙治疗无效。进行完整切除似乎很困难。塞来昔布和甲氨蝶呤是有效的治疗方法。我们的经验表明，塞来昔布和甲氨蝶呤可作为治疗无法切除的IMT的替代方案。
