School of Life Sciences, Systems Biology Research Centre, University of Skövde, Skövde, Sweden.
Inflamm Bowel Dis. 2013 Mar-Apr;19(4):881-8. doi: 10.1097/MIB.0b013e3182802c58.
Inflammatory bowel disease is characterized by a number of immunological alterations, not the least in the T-cell compartment. Numerous animal models of colitis have revealed aberrant thymocyte dynamics associated with skewed thymocyte development. The recent advancements in quantitative methods have proposed critical kinetic alterations in the thymocyte development during the progression of colitis. This review focuses on the aberrant thymocyte dynamics in Gαi2-deficient mice as this mouse model provides most quantitative data of the thymocyte development associated with colitis. Herein, we discuss several dynamic changes during the progression of colitis and propose a hypothesis for the underlying causes for the skewed proportions of the thymocyte populations seen in the Gαi2-deficient mice and in other mouse models of colitis.
炎症性肠病的特征是一系列免疫改变，尤其是 T 细胞区室。许多结肠炎动物模型揭示了与胸腺细胞发育异常相关的胸腺细胞动力学异常。最近定量方法的进展提出了在结肠炎进展过程中胸腺细胞发育的关键动力学改变。这篇综述重点介绍了 Gαi2 缺陷小鼠中的异常胸腺细胞动力学，因为该小鼠模型提供了与结肠炎相关的胸腺细胞发育的最定量数据。在这里，我们讨论了结肠炎进展过程中的几个动态变化，并提出了一个假设，即 Gαi2 缺陷小鼠和其他结肠炎小鼠模型中所见的胸腺细胞群体比例偏斜的潜在原因。
