Zhang Hua, Tao Yu-Fen, Shi Lei, Yao Yu-Feng, Xiang Hao, Lin Ke-Qin, Huang Xiao-Qin, Chu Jia-You, Shi Li
Chinese Academy of Medical Sciences, Kunming, China.
Yi Chuan. 2013 Feb;35(2):161-7. doi: 10.3724/sp.j.1005.2013.00161.
Recently, a 14 bp insertion/deletion polymorphism (+14 bp/-14 bp) in exon 8 of the human leucocyte antigen-G (HLA-G) gene has been widely recognized to associate with recurrent miscarriage, autoimmune diseases, hepatocellular carcinoma and other diseases. Our previous studies have shown the distribution characteristics of linguistic family for HLA-G 14 bp insertion/deletion in different ethnic groups. In the present study, we investigated the distribution of HLA-G 14 bp insertion/deletion polymorphism and their subsequent associations with HLA-A alleles in Tu, Yugu, Lisu and Nu ethnic populations based upon the HLA-A genotyping data. Our results showed that the frequencies of the 14 bp insertion/deletion polymorphism were diverse in these four populations while that in the same linguistic subfamily was similar. The significant difference in different linguistic subfamily except for Han and Mongolian language subfamily was identified. In addition, the 14 bp insertion was found to associate with HLA-A alleles in different ethnic populations.
最近，人类白细胞抗原-G（HLA-G）基因第8外显子中的14 bp插入/缺失多态性（+14 bp / -14 bp）已被广泛认为与复发性流产、自身免疫性疾病、肝细胞癌及其他疾病相关。我们之前的研究已经显示了不同种族中HLA-G 14 bp插入/缺失的语系分布特征。在本研究中，我们基于HLA-A基因分型数据，调查了土族、裕固族、傈僳族和怒族人群中HLA-G 14 bp插入/缺失多态性的分布及其与HLA-A等位基因的后续关联。我们的结果表明，这四种人群中14 bp插入/缺失多态性的频率各不相同，而同一语系分支中的频率相似。除汉藏语系和蒙古语系分支外，不同语系分支之间存在显著差异。此外，在不同种族人群中发现14 bp插入与HLA-A等位基因相关。
