Department of Neuropsychopharmacology, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo 187-8553, Japan.
Curr Neuropharmacol. 2012 Sep;10(3):231-8. doi: 10.2174/157015912803217314.
Recently, δ opioid receptor agonists have been proposed to be attractive targets for the development of novel antidepressants. Several studies revealed that single treatment of δ opioid receptor agonists produce antidepressant-like effects in the forced swimming test, which is one of the most popular animal models for screening antidepressants. In addition, subchronic treatment with δ opioid receptor agonists has been shown to completely attenuate the hyperemotional responses found in olfactory bulbectomized rats. This animal model exhibits hyperemotional behavior that may mimic the anxiety, aggression, and irritability found in depressed patients, suggesting that δ opioid receptor agonists could be effective in the treatment of these symptoms in depression. On the other hand, prototype δ opioid receptor agonists produce convulsive effects, which limit their therapeutic potential and clinical development. In this review, we presented the current knowledge regarding the antidepressant-like effects of δ opioid receptor agonists, which include some recently developed drugs lacking convulsive effects.
最近，δ 阿片受体激动剂被认为是开发新型抗抑郁药的有吸引力的靶点。几项研究表明，δ 阿片受体激动剂单次治疗可在强迫游泳试验中产生抗抑郁样作用，该试验是筛选抗抑郁药最常用的动物模型之一。此外，亚慢性给予 δ 阿片受体激动剂已被证明可完全减弱嗅球切除术大鼠中发现的过度情绪化反应。这种动物模型表现出过度情绪化的行为，可能模拟了抑郁患者中发现的焦虑、攻击和易怒，这表明 δ 阿片受体激动剂可能对抗抑郁患者的这些症状有效。另一方面，原型 δ 阿片受体激动剂产生惊厥作用，限制了它们的治疗潜力和临床开发。在这篇综述中，我们介绍了 δ 阿片受体激动剂的抗抑郁样作用的最新知识，包括一些最近开发的无惊厥作用的药物。
