HIV-1 突变谱在细胞类型间的变化。
Variation of HIV-1 mutation spectra among cell types.
机构信息
Institute for Molecular Virology, Department of Diagnostic and Biological Sciences, MinnCResT Program, School of Dentistry, University of Minnesota, Minneapolis, Minnesota, USA.
出版信息
J Virol. 2013 May;87(9):5296-9. doi: 10.1128/JVI.03576-12. Epub 2013 Feb 28.
Abstract
The high rates of mutation, recombination, and replication drive HIV-1 diversity. In this study, we investigated how cell type affects viral mutation rate and mutation spectra. In studying four different cell types, no differences in mutation rate were observed, but intriguingly cell type differences impacted HIV-1 mutation spectra. This is the first description of significant differences in HIV-1 mutation spectra observed in different cell types in the absence of changes in the viral mutation rate.
摘要
高突变率、重组率和复制率推动了 HIV-1 的多样性。在这项研究中，我们研究了细胞类型如何影响病毒突变率和突变谱。在研究四种不同的细胞类型时，我们没有观察到突变率的差异，但有趣的是，细胞类型的差异影响了 HIV-1 的突变谱。这是首次在病毒突变率不变的情况下，描述了不同细胞类型中 HIV-1 突变谱的显著差异。
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