Anastasia J V, Braun B L, Smith K T
Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, OH 45247.
Food Chem Toxicol. 1990 Mar;28(3):147-56. doi: 10.1016/0278-6915(90)90003-6.
Two semi-purified diets, identical except for protein (soya or casein), and a Purina chow diet were fed to groups of Sprague-Dawley rats and compared over a 22-month period for effects on body weight, organ weight, feed consumption, feed efficiency, protein efficiency, organ-to-body-weight ratios, certain organ mineral levels, gross pathology and histopathology. Feed efficiency, protein efficiency, body weight, and most organ weights were higher in the groups fed soya and casein, while feed consumption and most organ-to-body-weight ratios were relatively lower. Significant increases in the final pathology findings in the groups fed soya and casein included nephrocalcinosis (in females), hepatocellular vacuolization, gastric trichobezoars (hairballs), ulcerative pododermatitis (hock ulcers) and splenomegaly. This study demonstrates that the long-term feeding of semi-purified diets is feasible. Moreover, the differences observed between the protein sources, that is, soya and casein, were minimal, which suggests that either protein source is acceptable for long-term feeding studies.
将两种除蛋白质（大豆蛋白或酪蛋白）外其他成分相同的半纯化日粮以及一种普瑞纳（Purina）标准日粮喂给几组斯普拉格-道利（Sprague-Dawley）大鼠，并在22个月的时间里比较它们对体重、器官重量、采食量、饲料效率、蛋白质效率、器官与体重比、某些器官的矿物质水平、大体病理学和组织病理学的影响。喂食大豆蛋白和酪蛋白的组的饲料效率、蛋白质效率、体重和大多数器官重量较高，而采食量和大多数器官与体重比相对较低。喂食大豆蛋白和酪蛋白的组最终病理学检查结果的显著增加包括肾钙质沉着（雌性）、肝细胞空泡化、胃毛球、溃疡性足皮炎（跗关节溃疡）和脾肿大。本研究表明长期喂食半纯化日粮是可行的。此外，观察到的蛋白质来源（即大豆蛋白和酪蛋白）之间的差异很小，这表明两种蛋白质来源都可用于长期喂养研究。
