铜催化的酮与芳香腈的Aldol 型加成反应：一种合成烯胺酮的简单方法。
Copper-catalyzed aldol-type addition of ketones to aromatic nitriles: a simple approach to enaminone synthesis.
机构信息
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China.
出版信息
Chem Commun (Camb). 2013 Apr 11;49(28):2885-7. doi: 10.1039/c3cc40466h.
PMID:23450129
Abstract
An efficient method for the synthesis of enaminones is described. The aldol-type addition of ketones to aromatic nitriles proceeded smoothly in the presence of a simple copper catalyst system (CuI-2,2'-bipyridine-NaO(t)Bu) in N,N-dimethylformamide. Enaminones in satisfactory to excellent yields were produced using this technique.
摘要
描述了一种高效合成烯胺酮的方法。在简单的铜催化剂体系（CuI-2,2'-联吡啶-NaO(t)Bu）存在下，酮与芳香腈的羟醛型加成反应在 N,N-二甲基甲酰胺中顺利进行。使用该技术可获得令人满意至优秀产率的烯胺酮。
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