季节性过敏原的季节性特异性和 ARIA 分类在韩国的验证。
Seasonal Specificity of Seasonal Allergens and Validation of the ARIA Classification in Korea.
机构信息
Department of Otorhinolaryngology, Dankook University College of Medicine, Cheonan, Korea.
出版信息
Allergy Asthma Immunol Res. 2013 Mar;5(2):75-80. doi: 10.4168/aair.2013.5.2.75. Epub 2012 Nov 27.
PURPOSE
In Korea, tree pollens are known to be prevalent in spring, grass pollens in summer and weed pollens in autumn. However, few studies have revealed their seasonal specificity for allergic rhinitis symptoms. An ARIA (Allergic Rhinitis and its Impact on Asthma) classification of allergic rhinitis was recently introduced and its clinical validation has not been well proved. The aim of this study was to evaluate the seasonal specificity of seasonal allergens and to validate the ARIA classification with the conventional seasonal and perennial allergic rhinitis (SAR/PAR) classification.
METHODS
Two hundred twenty six patients with allergic rhinitis were included in this study. The patients were classified according to the sensitized allergens and the ARIA classifications. A questionnaire survey was performed and the data on the seasonal symptom score, the severity of symptoms and the SNOT (sinonasal outcome test)-20 score was obtained and the data was analyzed and compared between the conventional SAR/PAR classification and the ARIA classification.
RESULTS
Seasonal pollens (tree, grass, weed) were not specific to the pollen peak season and the patients' symptoms were severe during spring and autumn regardless of the offending pollens. More than 60% of the patients with SAR showed persistent symptoms and 33% of the patients with perennial allergic rhinitis (PAR) had intermittent symptoms, showing the lack of association between the SAR/PAR/PAR+SAR classification and the ARIA classification. The ARIA classification showed better association not only with the symptomatic score, but also with the SNOT-20 score, which showed better validity than the conventional SAR/PAR classifications.
CONCLUSIONS
Seasonal pollens were not specific to their season of prevalence in terms of the severity of symptoms, and the ARIA classification showed better representation of allergic symptoms and quality of life (SNOT-20 score) than did the SAR/PAR classification.
目的
在韩国，树花粉已知在春季流行，草花粉在夏季流行，杂草花粉在秋季流行。然而，很少有研究揭示它们对过敏性鼻炎症状的季节性特异性。最近引入了 ARIA（过敏性鼻炎及其对哮喘的影响）分类，其临床验证尚未得到很好的证明。本研究旨在评估季节性过敏原的季节性特异性，并通过常规季节性和常年性过敏性鼻炎（SAR/PAR）分类验证 ARIA 分类。
方法
本研究纳入了 226 例过敏性鼻炎患者。根据致敏过敏原和 ARIA 分类对患者进行分类。进行问卷调查，并获得季节性症状评分、症状严重程度和 SNOT（鼻-鼻窦结局测试）-20 评分的数据，并对常规 SAR/PAR 分类和 ARIA 分类之间的数据进行分析和比较。
结果
季节性花粉（树、草、杂草）与花粉高峰期无关，患者的症状在春季和秋季都很严重。超过 60%的 SAR 患者表现出持续性症状，33%的常年性过敏性鼻炎（PAR）患者有间歇性症状，表明 SAR/PAR/PAR+SAR 分类与 ARIA 分类之间缺乏关联。ARIA 分类不仅与症状评分有更好的相关性，而且与 SNOT-20 评分有更好的相关性，其有效性优于常规 SAR/PAR 分类。
结论
季节性花粉在症状严重程度方面与流行季节无关，ARIA 分类比 SAR/PAR 分类更能代表过敏症状和生活质量（SNOT-20 评分）。
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