Department of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, People's Republic of China.
PLoS One. 2013;8(2):e56918. doi: 10.1371/journal.pone.0056918. Epub 2013 Feb 25.
MDM2 is a major negative regulator of p53, and a single nucleotide polymorphism (SNP) in the MDM2 promoter region SNP309 has been demonstrated to be associated with an increased MDM2 expression and a significantly earlier age of onset of several tumors, including gastric cancer. Several studies were published to evaluate the association between SNP309 and gastric cancer risk. However, the results remain conflicting rather than conclusive.
The aim of this study was to assess the association between the MDM2 SNP309 polymorphism and gastric risk.
We performed a meta-analysis to investigate this relationship. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association. The pooled ORs were performed for codominant model, dominant model, and recessive model, respectively.
Five published case-control studies, including 1,621 gastric cancer cases and 2,639 controls were identified. We found that the MDM2 SNP309 polymorphism was associated with a significantly increased risk of gastric cancer risk when all studies were pooled into the meta-analysis (GG versus TT, OR = 1.54; 95%CI = 1.04-2.29, and GG versus GT/TT, OR = 1.49, 95%CI = 1.30-1.72). Furthermore, Egger's test did not show any evidence of publication bias (P = 0.799 for GG versus TT).
Our results suggest that the MDM2 SNP309 polymorphism may be a low-penetrant risk factor for the development of gastric cancer.
MDM2 是 p53 的主要负调控因子，其启动子区域的单核苷酸多态性（SNP）SNP309 已被证明与多种肿瘤（包括胃癌）的 MDM2 表达增加和发病年龄提前有关。已经发表了几项研究来评估 SNP309 与胃癌风险之间的关联。然而，结果仍然存在争议，而不是结论性的。
本研究旨在评估 MDM2 SNP309 多态性与胃癌风险之间的关联。
我们进行了荟萃分析来研究这种关系。使用比值比（ORs）和 95%置信区间（CIs）来评估关联的强度。分别使用共显性模型、显性模型和隐性模型进行合并 ORs 分析。
共纳入了 5 项已发表的病例对照研究，包括 1621 例胃癌病例和 2639 例对照。我们发现，当所有研究都纳入荟萃分析时，MDM2 SNP309 多态性与胃癌风险显著增加相关（GG 与 TT，OR=1.54；95%CI=1.04-2.29，GG 与 GT/TT，OR=1.49，95%CI=1.30-1.72）。此外，Egger 检验未显示出任何发表偏倚的证据（GG 与 TT 的 P=0.799）。
我们的结果表明，MDM2 SNP309 多态性可能是胃癌发生的低外显度风险因素。
