School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
PLoS One. 2013;8(2):e57447. doi: 10.1371/journal.pone.0057447. Epub 2013 Feb 22.
Depression is a common, recurrent, and debilitating problem and Internet delivered cognitive behaviour therapy (iCBT) could offer one solution. There are at least 25 controlled trials that demonstrate the efficacy of iCBT. The aim of the current paper was to evaluate the effectiveness of an iCBT Program in primary care that had been demonstrated to be efficacious in two randomized controlled trials (RCTs).
Quality assurance data from 359 patients prescribed the Sadness Program in Australia from October 2010 to November 2011 were included.
Intent-to-treat marginal model analyses demonstrated significant reductions in depressive symptoms (PHQ9), distress (K10), and impairment (WHODAS-II) with medium-large effect sizes (Cohen's d = .51-1.13.), even in severe and/or suicidal patients (Cohen's d = .50-1.49.) Secondary analyses on patients who completed all 6 lessons showed levels of clinically significant change as indexed by established criteria for remission, recovery, and reliable change.
The Sadness Program is effective when prescribed by primary care practitioners and is consistent with a cost-effective stepped-care framework.
抑郁症是一种常见的、反复发作的、使人虚弱的问题,而互联网提供的认知行为疗法(iCBT)可能是一种解决方案。至少有 25 项对照试验证明了 iCBT 的疗效。本文的目的是评估在两项随机对照试验(RCT)中已证明有效的初级保健中的 iCBT 计划的有效性。
纳入了 2010 年 10 月至 2011 年 11 月期间在澳大利亚为 359 名患者开处方 Sadness 计划的质量保证数据。
意向治疗边缘模型分析表明,抑郁症状(PHQ9)、痛苦(K10)和障碍(WHODAS-II)显著减轻,具有中等至较大的效应量(Cohen's d=0.51-1.13),即使是严重和/或有自杀倾向的患者(Cohen's d=0.50-1.49)。对完成所有 6 节课的患者进行的二次分析显示,根据既定的缓解、恢复和可靠变化标准,临床显著变化的水平。
初级保健医生开处方时,Sadness 计划是有效的,并且符合成本效益的分级护理框架。