Department of Ultrasound of Obstetrics and Gynecology, First of Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Ultrasound Med Biol. 2013 May;39(5):761-8. doi: 10.1016/j.ultrasmedbio.2012.11.008. Epub 2013 Feb 27.
The main purpose of this study was to determine whether three-dimensional contrast-enhanced ultrasound (3D-CEUS) can provide useful information to distinguish malignant from benign adnexal masses (≤4 cm). Forty-seven patients with 51 adnexal masses were examined with 3D-CEUS. The sonographic features of masses were analyzed. All diagnoses were confirmed by surgical pathology and long-term follow-up results. The 51 masses included 43 benign and 8 malignant lesions. On 3D-CEUS images, benign lesions appeared as round structures formed by sparse and straight capillary vessels. Malignant lesions showed irregular stereo structures with dense and tortuous vascular distribution. A 3D-CEUS scoring system was established. There were no statistically significant differences in scores at each time point between the 20th and 70th seconds, and the area under the receiver operating characteristic curve for this time period was the largest (0.995). A cut-off score of 8 was established, with scores ≥8 being suggestive of malignancy. The 3D-CEUS scoring system had a high sensitivity (100%) and specificity (98%). 3D-CEUS is likely to be the new tool to distinguish malignant from benign small adnexal masses and diagnose early ovarian cancer.
本研究的主要目的是确定三维对比增强超声（3D-CEUS）是否能提供有用的信息来区分≤4cm 的附件区良恶性肿块。47 例 51 个附件区肿块患者进行了 3D-CEUS 检查。分析了肿块的超声特征。所有诊断均经手术病理和长期随访结果证实。51 个肿块中，良性 43 个，恶性 8 个。在 3D-CEUS 图像上，良性病变表现为稀疏、直的毛细血管构成的圆形结构。恶性病变显示出不规则的立体结构，血管分布密集且扭曲。建立了 3D-CEUS 评分系统。20 秒和 70 秒时，各时间点的评分无统计学差异，此时间段的受试者工作特征曲线下面积最大（0.995）。确定 8 分为截断值，评分≥8 提示恶性可能。3D-CEUS 评分系统具有较高的灵敏度（100%）和特异性（98%）。3D-CEUS 可能成为区分附件区良恶性小肿块和诊断早期卵巢癌的新工具。
