Department of Psychology, Queens College and The Graduate Center, City University of New York (CUNY), Flushing, NY, USA.
Ann Epidemiol. 2013 Apr;23(4):189-92. doi: 10.1016/j.annepidem.2013.01.003. Epub 2013 Feb 28.
Previous studies have suggested an association between mood and anxiety disorders and peptic ulcer, yet extant work suffers from methodologic limitations. Centrally, previous epidemiologic studies have relied exclusively on self-report of ulcer. This study aimed to investigate the relationship between DSM-IV depression and anxiety disorders and physician-diagnosed ulcer among adults in the general population.
Data were drawn from a population-based, representative sample of 4181 adults aged 18 to 79 in the German National Health Interview and Examination Survey.
Any anxiety disorder (odds ratio [OR], 2.6), panic disorder (OR, 5.2), panic attacks (OR, 3.8), and social phobia (OR, 3.3) were associated with increased likelihood of physician-diagnosed ulcer, compared with those without ulcer. There was evidence of a dose-response relationship between number of mental disorders and likelihood of current ulcer.
These findings provide initial evidence of a link between anxiety disorders and physician-diagnosed ulcer among adults in the community. Future work, ideally taking into account Helicobacter pylori infection, stress, and mental health problems is needed to improve our understanding of the possible mechanisms that can provide insight into the etiology of peptic ulcers.
先前的研究表明，情绪和焦虑障碍与消化性溃疡之间存在关联，但现有研究存在方法学上的局限性。以前的流行病学研究主要依赖于溃疡的自我报告。本研究旨在调查普通人群中 DSM-IV 抑郁和焦虑障碍与医生诊断的溃疡之间的关系。
数据来自德国国家健康访谈和体检调查，该调查是一项基于人群的代表性样本，共包括 4181 名年龄在 18 至 79 岁的成年人。
与没有溃疡的人相比，任何焦虑障碍（优势比 [OR]，2.6）、恐慌症（OR，5.2）、恐慌发作（OR，3.8）和社交恐惧症（OR，3.3）都与医生诊断的溃疡可能性增加有关。精神障碍的数量与当前溃疡的可能性之间存在剂量反应关系。
这些发现为社区成年人中焦虑障碍与医生诊断的溃疡之间的联系提供了初步证据。未来的工作，理想情况下应考虑幽门螺杆菌感染、压力和心理健康问题，以提高我们对可能的机制的理解，从而深入了解消化性溃疡的病因。
