Makulu D R, Waalkes T P
J Natl Cancer Inst. 1975 Feb;54(2):305-9.
Interaction between aromatic diamidines (pentamidine, propamidine, and stilbamidine) and nucleic acids were studied to elucidate the mechanism underlying renal toxicity included by pentamidine in patients. Pentamidine, propamidine, and stilbamidine precipitated with RNA and DNA of all species and types. Furthermore, the diamidines interacted and precipitated with all nucleoside triphosphates and nucleoside diphosphates, but not with nucleoside monophosphates, nucleosides, or free bases. Nucleoside diphosphate is the minimum unit necessary for interaction with the diamidines. This interaction between diamidines and nucleotides or nucleic acids may be implicated in the etiology of renal damage and skin reactions associated with these drugs.
研究了芳香二脒（喷他脒、丙脒和双脒苯脲）与核酸之间的相互作用，以阐明喷他脒所致患者肾毒性的潜在机制。喷他脒、丙脒和双脒苯脲可与所有物种和类型的RNA和DNA发生沉淀反应。此外，这些二脒与所有三磷酸核苷和二磷酸核苷相互作用并发生沉淀，但不与单磷酸核苷、核苷或游离碱发生反应。二磷酸核苷是与二脒相互作用所需的最小单位。二脒与核苷酸或核酸之间的这种相互作用可能与这些药物相关的肾损伤和皮肤反应的病因有关。
