Department of Immunology and Molecular Medicine Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India.
Blood Cells Mol Dis. 2013 Jun;51(1):56-60. doi: 10.1016/j.bcmd.2013.02.001. Epub 2013 Feb 27.
Vitamin D regulates many biological processes including bone metabolism, innate immune response, and cell proliferation and differentiation by binding to its receptor VDR. Vitamin D receptor (VDR) gene polymorphisms have been associated with many cancers like breast, colorectal, prostate, and skin. The main aim of this study was to determine whether VDR polymorphisms (ApaI, BsmI and FokI) are associated with increased risk of multiple myeloma.
We designed a case control study where 75 multiple myeloma cases were studied for VDR polymorphisms (ApaI, BsmI and FokI) against 150 controls taken from general population. The polymorphisms of VDR gene were investigated using PCR-RFLP method.
We did not find any significant association between ApaI and BsmI polymorphisms and multiple myeloma risk (P>0.05), but FokI polymorphism was significantly associated with increased risk for multiple myeloma. We also found a significant association between the ff variant genotype with creatinine levels, albumin levels, and Durie-Salmon stage III.
Our findings suggest that the FokI polymorphism is involved in the increased susceptibility to development and progression in multiple myeloma in the ethnic Kashmiri population. Furthermore these results suggest that ff genotype is associated with higher risk for developing multiple myeloma.
维生素 D 通过与其受体 VDR 结合来调节许多生物学过程，包括骨骼代谢、先天免疫反应、细胞增殖和分化。维生素 D 受体 (VDR) 基因多态性与许多癌症有关，如乳腺癌、结直肠癌、前列腺癌和皮肤癌。本研究的主要目的是确定 VDR 多态性 (ApaI、BsmI 和 FokI) 是否与多发性骨髓瘤的风险增加有关。
我们设计了一项病例对照研究，其中研究了 75 例多发性骨髓瘤病例的 VDR 多态性 (ApaI、BsmI 和 FokI)，并与来自普通人群的 150 名对照进行了比较。使用 PCR-RFLP 方法研究了 VDR 基因的多态性。
我们没有发现 ApaI 和 BsmI 多态性与多发性骨髓瘤风险之间存在任何显著关联 (P>0.05)，但 FokI 多态性与多发性骨髓瘤风险增加显著相关。我们还发现 ff 变异基因型与肌酐水平、白蛋白水平和 Durie-Salmon 分期 III 之间存在显著关联。
我们的研究结果表明，FokI 多态性与克什米尔族群多发性骨髓瘤的易感性增加和进展有关。此外，这些结果表明 ff 基因型与多发性骨髓瘤的发病风险增加有关。
