Department of General Pathology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Nutrients. 2022 Apr 26;14(9):1802. doi: 10.3390/nu14091802.
Multiple myeloma (MM) is a plasma cell malignancy with multifactorial etiology. One of the underlying mechanisms is immune system dysregulation. Immunotherapy is being widely introduced into various MM treatment protocols. Nevertheless, little is known about boosting the immune system with supportive treatment. Although classical actions of vitamin D (VD) are very well established, their non-classical actions related to the modulation of the immune system in MM are still a subject of ongoing research. In this literature review, we intend to summarize research conducted on VD and MM, both in vitro and in vivo, with particular emphasis on immune system modulation, the induction of the differentiation of malignant MM cells, synergic activity with anti-MM drugs, and MM-associated peripheral neuropathy.
多发性骨髓瘤（MM）是一种具有多因素病因的浆细胞恶性肿瘤。其中一个潜在机制是免疫系统失调。免疫疗法正被广泛引入各种 MM 治疗方案中。然而，对于支持性治疗如何增强免疫系统，我们知之甚少。尽管维生素 D（VD）的经典作用已得到充分证实，但它们与 MM 中免疫系统调节相关的非经典作用仍在研究中。在这篇文献综述中，我们旨在总结在体外和体内研究 VD 和 MM 的相关研究，特别强调免疫系统调节、诱导恶性 MM 细胞分化、与抗 MM 药物的协同活性以及 MM 相关周围神经病。
