Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room 4C110, 10 Center Drive, MSC 1367, Bethesda, MD, USA.
Psychiatry Res. 2013 Apr 30;212(1):1-6. doi: 10.1016/j.pscychresns.2012.10.012. Epub 2013 Mar 1.
Neuroimaging studies have implicated the corpus callosum (CC) in the pathophysiology of obsessive-compulsive disorder (OCD). Putative dysfunctions in prefrontal cortical regions suggest anomalies in anterior segments of the CC. However, recent studies have also implicated the middle and posterior CC. The present study soughts to examine the CC using parcellation scheme informed by diffusion tensor imaging. Anatomic brain magnetic resonance scans were obtained from 21 OCD subjects (mean age=26.9 ± 9.93) and 42 healthy age- and sex-matched controls (mean age=26.6 ± 9.46) between the ages of 14 and 49. Area and volume measures of five subregions of the CC were obtained via manual tracings. A multivariate analysis of variance (after correcting for multiple comparisons) identified smaller area and volume in the mid-anterior region of the CC in OCD patients relative to controls. These findings implicate medio-frontal regions of the cortex in the pathophysiology of OCD.
神经影像学研究表明，胼胝体（CC）在强迫症（OCD）的病理生理学中起作用。假设前额皮质区域的功能障碍表明 CC 的前节存在异常。然而，最近的研究也牵连到中间和后部 CC。本研究旨在使用扩散张量成像提供的分割方案检查 CC。从 14 岁至 49 岁的 21 名 OCD 患者（平均年龄=26.9±9.93）和 42 名年龄和性别匹配的健康对照者（平均年龄=26.6±9.46）中获得了大脑磁共振扫描。通过手动追踪获得了 CC 的五个亚区的面积和体积测量值。在进行了多次比较校正的多元方差分析后，发现 OCD 患者 CC 的中前区域的面积和体积较小。这些发现表明 OCD 的病理生理学涉及大脑的中额区域。
