Centre for Addiction and Mental Health, Toronto, Canada.
J Affect Disord. 2011 Sep;133(1-2):300-4. doi: 10.1016/j.jad.2011.03.041. Epub 2011 May 4.
This study aimed to determine the distributions of the age at onset (AAO) using mixture analysis and better develop the understanding of AAO as a clinical feature of obsessive-compulsive disorder.
Mixture analysis was used to identify sub-groups characterized by differences in AAO. Clinical features were analyzed for differences in AAO sub-groups using mixture analysis. Comparisons were made with AAO cut-offs used in previous studies using the 2-Sample Kolmogorov-Smirnov Test.
Mixture analysis of our sample (n=196) yielded a combination of 2 normal theoretical distributions with means (SD) of 9.66 (3.12) for the early-onset sub-group and 21.1 (8.36) years for the late-onset sub-group. The sub-groups were divided by a cut-off of 15 years. As expected, a negative correlation was found between AAO and duration of illness. The early-onset subjects had significantly lower age at the time of the assessment and they tended to have more often panic attacks but were treated less often with benzodiazepines and other anti-anxiety medications. The comparison analysis showed significant difference in the AAO distribution between our sample and four other study samples.
Our findings support the notion that different AAO sub-groups correspond with differences in clinical presentations of obsessive-compulsive disorder.
本研究旨在通过混合分析确定发病年龄（AAO）的分布，从而更好地了解 AAO 作为强迫症的临床特征。
使用混合分析来识别以 AAO 差异为特征的亚组。使用混合分析对 AAO 亚组的临床特征进行分析。使用 2 样本 Kolmogorov-Smirnov 检验与先前研究中使用的 AAO 截止值进行比较。
对我们的样本（n=196）进行混合分析，得出了 2 个正态理论分布的组合，其中早发亚组的平均值（SD）为 9.66（3.12），晚发亚组的平均值为 21.1（8.36）。亚组以 15 岁为界。正如预期的那样，AAO 与疾病持续时间呈负相关。早发组的评估年龄明显较低，他们往往更频繁地出现惊恐发作，但较少接受苯二氮䓬类药物和其他抗焦虑药物治疗。比较分析表明，我们的样本与其他四个研究样本的 AAO 分布存在显著差异。
我们的研究结果支持这样一种观点，即不同的 AAO 亚组与强迫症的临床表现存在差异相对应。
