Udo Erik O, van Hemel Norbert M, Zuithoff Nicolaas P A, Nijboer Heidi, Taks William, Doevendans Pieter A, Moons Karel G M
Department of Cardiology, UMC Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands; Julius Center for Health Sciences and Primary Care, UMC Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
Int J Cardiol. 2013 Oct 3;168(3):2159-63. doi: 10.1016/j.ijcard.2013.01.253. Epub 2013 Feb 28.
Health-related quality of life (HRQoL) values shortly after pacemaker (PM) implantation for bradycardia have been established, however little is known about long-term HRQoL.
Using the generic SF-36 and the PM specific Aquarel questionnaire, HRQoL was repeatedly measured during a 7.5 year follow-up period in 881 bradycardia PM recipients included in the large scale nationwide Dutch FOLLOWPACE study. HRQoL over time, corrected for age, gender, diabetes, hypertension, heart failure, cardiovascular disease and AV-synchrony, was assessed with a linear mixed model.
Increased scores both on overall SF-36 and on all SF-36 subscales were observed shortly after implantation. Although scores on SF-36 gradually declined over time, scores remained improved over the measured pre-implantation values. Also, scores for almost all subscales remained increased throughout the 7.5 year observation period, except for physical functioning which showed a gradual decline several years after the initial rise. Additionally, higher scores on all Aquarel scales were observed after implantation. Scores on the arrhythmias and chest discomfort subscales improved and remained stable throughout follow-up (FU), whereas the dyspnea at exertion subscale showed a gradual decline during FU to reach pre-implantation values at 5 years.
Increased HRQoL is observed not only shortly after PM implantation, but also after long-term FU.
ClinicalTrials.gov Identifier: NCT00135174; http://www.clinicaltrials.gov/ct2/show/NCT00135174.
已确定心动过缓患者植入起搏器（PM）后不久的健康相关生活质量（HRQoL）值，但对长期HRQoL了解甚少。
在荷兰全国性大规模FOLLOWPACE研究纳入的881例心动过缓PM接受者中，使用通用的SF-36和PM特异性Aquarel问卷，在7.5年的随访期内反复测量HRQoL。采用线性混合模型评估随时间变化的HRQoL，并对年龄、性别、糖尿病、高血压、心力衰竭、心血管疾病和房室同步性进行校正。
植入后不久，整体SF-36及其所有子量表的得分均有所提高。尽管SF-36得分随时间逐渐下降，但仍高于植入前测量值。此外，在7.5年的观察期内，几乎所有子量表的得分均保持上升，除了身体功能在最初上升几年后逐渐下降。此外，植入后所有Aquarel量表的得分均较高。心律失常和胸部不适子量表的得分在整个随访（FU）期间有所改善并保持稳定，而运动时呼吸困难子量表在FU期间逐渐下降，在5年时达到植入前值。
不仅在PM植入后不久，而且在长期FU后，HRQoL均有所提高。
ClinicalTrials.gov标识符：NCT00135174；http://www.clinicaltrials.gov/ct2/show/NCT00135174 。
