Hiraoka N, Yoshikawa T, Kondo M, Nishioka H, Goto I, Fukuoka J, Ohsawa A, Yokoh S
First Department of Medicine, Kyoto Prefectural University of Medicine.
Masui. 1990 Mar;39(3):367-71.
Leukocyte elastase (LE) plays a role in the development of shock. Therefore, we examined the effects of urinastatin, a protease inhibitor, on LE in 7 patients with sepsis. LE levels before the administration of urinastatin were high in all patients, especially those in shock. Administration of urinastatin markedly decreased LE levels, with the decrease being more remarkable in patients showing high LE levels before treatment. These results suggest that urinastatin not only reduces LE levels but also suppresses factors that are involved in the development of septic shock.
白细胞弹性蛋白酶（LE）在休克的发展过程中起作用。因此，我们研究了蛋白酶抑制剂乌司他丁对7例脓毒症患者LE的影响。所有患者在给予乌司他丁前LE水平均较高，尤其是休克患者。给予乌司他丁后LE水平显著降低，治疗前LE水平高的患者下降更为明显。这些结果表明，乌司他丁不仅能降低LE水平，还能抑制参与脓毒症休克发展的因素。
