Indiana University School of Medicine, Indianapolis, Indiana, USA.
J Clin Invest. 2013 Mar;123(3):1003-4. doi: 10.1172/JCI67166. Epub 2013 Mar 1.
Insulin resistance is typically defined as a reduced ability of insulin to induce glucose uptake by target tissues such as fat and skeletal muscle cells. It accompanies several disease states, including obesity, type 2 diabetes, hepatitis C, and polycystic ovary syndrome, and is a primary feature of metabolic syndrome. Outside of its effects on blood glucose levels, insulin resistance is also associated with a 2- to 3-fold increased risk of cardiovascular mortality. In 1996, Alain Baron, Helmut Steinberg, and colleagues demonstrated that insulin resistance is associated with endothelial dysfunction. This seminal observation led to significant advances in our understanding of insulin's action in health and disease.
胰岛素抵抗通常被定义为胰岛素诱导脂肪和骨骼肌细胞等靶组织摄取葡萄糖的能力降低。它伴随着多种疾病状态，包括肥胖症、2 型糖尿病、丙型肝炎和多囊卵巢综合征，也是代谢综合征的主要特征。除了对血糖水平的影响外，胰岛素抵抗还与心血管死亡率增加 2 至 3 倍相关。1996 年，Alain Baron、Helmut Steinberg 和同事证明胰岛素抵抗与内皮功能障碍有关。这一重要观察结果使我们对胰岛素在健康和疾病中的作用的理解取得了重大进展。
