Rahiminejad Mohammad Saeid, Mirmohammad Sadeghi Mehrdad, Mohammadinejad Payam, Sadeghi Bamdad, Abolhassani Hassan, Dehghani Firoozabadi Mohammad Mehdi, Fathi Seyed Mohammad, Rezvani Hamid, Bahoush Gholamreza, Ehsani Mohammad Ali, Faranoush Mohammad, Mehrvar Azim, Torabi Sagvand Babak, Ghadiani Mojtaba, Rezaei Nima, Aghamohammadi Asghar
Research Center for Immunodeficiencies, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Allergy Asthma Immunol. 2013 Mar;12(1):50-6.
Coincidence of autoimmune diseases such as immune thrombocytopenic purpura (ITP) with immunodeficiencies has been reported previously in patients who suffered from primary antibody deficiency (PAD). But there is no original study on immunological profiles of ITP patients to find out their probable immune deficiency. In this case-control study, ITP patients' humoral immunity was investigated for diagnosis of PAD in comparison with normal population. To evaluate the humoral immune system against polysaccharide antigens, patients' serum immunoglobulin levels were measured and a 23-valent pneumococcal capsular polysaccharide vaccine (PPV23) was administrated to evaluate the antibody response to vaccination. In this study, 14 out of 36 patients (39%) were diagnosed with antibody mediated immune deficiency including 2 patients (5.5%) with immunoglobulin class deficiency and 4 (11%) with IgG subclass deficiency. The remaining patients suffered from specific antibody deficiency. The most frequent deficiency in ITP patients was specific antibody deficiency.Therefore, immunological survey on ITP patients may be important especially for those who have undergone splenectomy.
免疫性血小板减少性紫癜（ITP）等自身免疫性疾病与免疫缺陷的巧合此前已在患有原发性抗体缺陷（PAD）的患者中有所报道。但尚无关于ITP患者免疫特征的原创性研究以查明其可能存在的免疫缺陷。在这项病例对照研究中，与正常人群相比，对ITP患者的体液免疫进行了研究以诊断PAD。为评估针对多糖抗原的体液免疫系统，测量了患者的血清免疫球蛋白水平，并接种了23价肺炎球菌荚膜多糖疫苗（PPV23）以评估对疫苗接种的抗体反应。在本研究中，36例患者中有14例（39%）被诊断为抗体介导的免疫缺陷，其中2例（5.5%）为免疫球蛋白类别缺陷，4例（11%）为IgG亚类缺陷。其余患者患有特异性抗体缺陷。ITP患者中最常见的缺陷是特异性抗体缺陷。因此，对ITP患者进行免疫学检查可能很重要，尤其是对于那些已经接受脾切除术的患者。
