Department of Pediatrics, Faculty of Medicine, Ali-Asghar Children Hospital, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Preventive Medicine and Public Health Research Center, Psychosocial Health Research Institute, Department of Community and Family Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Sci Rep. 2020 Jul 16;10(1):11717. doi: 10.1038/s41598-020-68647-2.
Atopic dermatitis (AD) is a chronic disease affecting 10-30% of children and 2-10% of adults worldwide. It is manifested by the pruritus eczema lesions on the skin. Immune thrombocytopenic purpura (ITP) is the most common cause of acute onset of thrombocytopenia in childhood. The aim of this study was association of primary immune thrombocytopenic purpura and atopia among children. This case control study was performed on patients with acute and chronic ITP who were confirmed by a hematologist. The control group was also selected from the siblings of the patients who were healthy and almost matched by age and sex with the patient group. Data were entered into a questionnaire under the SPSS-20 program, and demographic data were analyzed descriptively. In the present study, 120 patients were enrolled, 60 of whom were in the patient group and 60 in the control group. Mean age was 95 and 98 months for patients and control. This study showed a significant association of ITP with allergic rhinitis (P = 0.02), atopic dermatitis (P = 0.004), itching (P = 0.042), and dry skin (P = 0.015). However, no significant relationship was found between ITP and asthma (P-value = 0.18). This study does not reveal the causality between atopy and ITP but clearly shows the association between atopy and ITP disease, so the prevalence of atopy in ITP patients is higher than the normal population. According to the results of this study, it is necessary to investigate the cause of atopy and ITP and to find other immunological and possibly genetic commonalities.
特应性皮炎（AD）是一种全球性疾病，影响全球 10-30%的儿童和 2-10%的成年人。其特征为皮肤瘙痒性湿疹样皮损。免疫性血小板减少性紫癜（ITP）是儿童急性血小板减少症最常见的原因。本研究旨在探讨儿童原发性免疫性血小板减少症（ITP）与特应性之间的关系。本病例对照研究纳入了经血液科医生确诊的急性和慢性 ITP 患者。对照组也从患者的兄弟姐妹中选择，这些兄弟姐妹身体健康，且在年龄和性别上与患者组几乎匹配。数据被输入 SPSS-20 程序下的问卷中，采用描述性统计方法分析人口统计学数据。本研究共纳入 120 例患者，其中 60 例为患者组，60 例为对照组。患者组和对照组的平均年龄分别为 95 和 98 个月。本研究表明，ITP 与过敏性鼻炎（P=0.02）、特应性皮炎（P=0.004）、瘙痒（P=0.042）和皮肤干燥（P=0.015）显著相关。然而，ITP 与哮喘之间无显著相关性（P 值=0.18）。本研究并未揭示特应性与 ITP 之间的因果关系，但清楚地表明了特应性与 ITP 疾病之间的关联，因此 ITP 患者中特应性的患病率高于正常人群。根据本研究结果，有必要调查特应性和 ITP 的病因，并寻找其他免疫和可能的遗传共性。
