Azimi Mohamadabadi Maryam, Hassan Zuhair Muhammad, Zavaran Hosseini Ahmad, Noori Shekoofe, Mahdavi Mehdi, Maroufizadeh Saman, Maroof Hamidreza
Department of Immunology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Iran J Allergy Asthma Immunol. 2013 Mar;12(1):57-62.
Recent studies have indicated the profound anti-tumor activity of artemisinin's compounds, among which; arteether is an oil-soluble derivative of artemisinin with an endoperoxide bridge that can induce apoptosis in tumor cells but not in the normal cells. An experiment was carried out on tumor-bearing Balb/c mice to estimate the effects of Arteether on tumor growth and antitumor immune responses. Briefly, 6mg/kg/day of Arteether and diluents were administered to two groups of mice. Tumor sizes were measured using digital verniercallipers. Mice were sacrificed and splenocytes were harvested for lymphocyte proliferation assay, the level of IL-4 and IFN-γ cytokines, and the percentage of splenic T regulatory cells were measured. According to the findings, there were no statistical differences between the groups with respect to the level of IFN-γ, IL-4 and proliferation assay; while our results showed that Arteether is effective in the reduction of tumor growth rate. In general, intra-tumoral injection of Arteether as an oil-soluble derivative of artemisinin brings to light some antitumor properties that may aid in development of more effective antitumor agents.
最近的研究表明青蒿素类化合物具有显著的抗肿瘤活性，其中蒿甲醚是青蒿素的一种油溶性衍生物，带有一个内过氧化物桥，它能诱导肿瘤细胞凋亡，但对正常细胞无此作用。对荷瘤Balb/c小鼠进行了一项实验，以评估蒿甲醚对肿瘤生长和抗肿瘤免疫反应的影响。简要来说，将6mg/kg/天的蒿甲醚和稀释剂分别给予两组小鼠。使用数字游标卡尺测量肿瘤大小。处死小鼠并收集脾细胞用于淋巴细胞增殖试验，检测白细胞介素-4（IL-4）和干扰素-γ（IFN-γ）细胞因子水平以及脾调节性T细胞的百分比。根据研究结果，两组在IFN-γ、IL-4水平和增殖试验方面无统计学差异；而我们的结果表明蒿甲醚可有效降低肿瘤生长速率。总体而言，瘤内注射作为青蒿素油溶性衍生物的蒿甲醚揭示了一些抗肿瘤特性，这可能有助于开发更有效的抗肿瘤药物。
